Endrin animal toxicology study

ENDRIN A-2

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ENDRIN A-2 APPENDIX A ... Although human data are preferred, MRLs often must be based on animal studies because relevant human studies are lacking. In the absence of evidence to the contrary, ATSDR assumes ... mg/kg/day endrin for 2 years. Effects Noted in Study and Corresponding Doses: Concentrations less than 0.05 mg/kg/day endrin in the

ENDRIN A-2

DFBKLUNHFCTMDC-QINJUESRSA-N | C12H8Cl6O - PubChem

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After absorption, endrin is partly retained in the fatty tissues and partly excreted in the urine and feces unchanged and as three metabolites. Endrin is more rapidly excreted than dieldrin; rats, on a daily oral dose of 0.32 mg/kg, reached a state of equilibrium after 5 or 6 days. The biologic half-life was 3 days in male rats, 4 days in ...

DFBKLUNHFCTMDC-QINJUESRSA-N | C12H8Cl6O - PubChem

ATSDR - Public Health Statement: Endrin (Endrin aldehyde)

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1/21/2015 · Endrin is a solid, white, almost odorless substance that was used as a pesticide to control insects, rodents, and birds. Endrin has not been produced or sold for general use in the United States since 1986. Little is known about the properties of endrin aldehyde, an impurity and breakdown product of endrin, or endrin ketone, which is a product of endrin when it is exposed to light.

ATSDR - Public Health Statement: Endrin (Endrin aldehyde)

Endrin (72-20-8) | Chemical Effects in Biological Systems

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McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded ...

Endrin (72-20-8) | Chemical Effects in Biological Systems

Endrin [MAK Value Documentation, 2002] - - - Major ...

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Dermal exposure of rabbits to endrin (solid) doses of 75 mg/animal and day for a period of up to 14 weeks, for 2 hours a day on 5 days a week, led to symptoms of intoxication such as seizures, tremor and facial twitching, and to death of 1 of 3 animals. ... In another study, single endrin doses of 5 mg/kg body weight administered on days 7, 8 ...

Endrin [MAK Value Documentation, 2002] - - - Major ...

Pesticide Toxicity, Toxicity of Endrin for Laboratory Animals

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Pesticide Toxicity, Toxicity of Endrin for Laboratory Animals Article in Journal of Agricultural and Food Chemistry 3(10) · October 1955 with 7 Reads DOI: 10.1021/jf60056a003

Pesticide Toxicity, Toxicity of Endrin for Laboratory Animals

Endrin; CASRN 72-20-8 - cfpub.epa.gov

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Endrin; CASRN 72-20-8. Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . IRIS assessment development process. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and

Endrin; CASRN 72-20-8 - cfpub.epa.gov

Endrin aldehyde | C12H8Cl6O - PubChem

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Endrin aldehyde is a minor impurity of the pesticide endrin which is no longer produced. Production and use of endrin may have resulted in endrin aldehyde's release to the environment through direct release to the environment through direct release of endrin or from various waste streams from the production of endrin. If released to air, an ...

Endrin aldehyde | C12H8Cl6O - PubChem

A surprising case of endrin poisoning in dogs - ScienceDirect

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COMMENTARYASE REPORT A surprising case of endrin poisoning in dogs MP QUICK and IC SHAW Toxicology Section, Biochemistry Department Central Veterinary Laboratory, New Haw, Weybridge Surrey, United Kingdom KT153NB and PA MANSER Veterinary Investigation Centre Madingley Road, Cambridge, United Kingdom CB3 OER A case of possible malicious poisoning of dogs by endrin was …

A surprising case of endrin poisoning in dogs - ScienceDirect

Endrin and dieldrin: A comparison of hepatic excretion in ...

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TOXICOLOGY AND APPLIED PHARMACOLOGY 16, 547-555 (1970) Endrin and Dieldrin: A Comparison of Hepatic Excretion in the Rat 1-3 J. F. COLE,4 L. M. KLEVAY, AND M. R. ZAVONS Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219 Received January 21, 1969 Endrin and Dieldrin: A Comparison of Hepatic Excretion in the Rat.

Endrin and dieldrin: A comparison of hepatic excretion in ...

Provisional Peer Reviewed Toxicity Values for Endrin ...

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The animal carcinogenicity data for endrin have previously been characterized as inadequate by U.S. EPA (1992, 2001). Negative results were reported for two strains of mice, but one study was confounded by high mortality among low-dose males because of accidental overdosing. Negative results in a dog study were considered inconclusive because ...

Provisional Peer Reviewed Toxicity Values for Endrin ...

Human Elimination of Organochlorine Pesticides: Blood ...

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10/5/2016 · The metabolites DDE and endrin ketone were not detected in any urine samples. Of the parent compounds, DDT, methoxychlor, and endrin as well as the metabolites DDE, DDD, and endosulfan sulfate appear to be readily excreted into sweat as they are found in over half of the participants examined (Table 5). Additionally, with the exception of DDE ...

Human Elimination of Organochlorine Pesticides: Blood ...

environmental toxicology Flashcards and Study Sets | Quizlet

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Learn environmental toxicology with free interactive flashcards. Choose from 500 different sets of environmental toxicology flashcards on Quizlet.

environmental toxicology Flashcards and Study Sets | Quizlet

Environmental Medicine: Integrating a Missing Element into ...

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For over 35 years, chlordane was used as an agricultural insecticide and for termite control in and around homes. EPA estimates that 19.5 million structures have been treated with chlordane; as many as 52 million occupants may be exposed. Chlordane can persist in the environment for more than 30 ...

Environmental Medicine: Integrating a Missing Element into ...

International Notes Acute Convulsions Associated with ...

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International Notes Acute Convulsions Associated with Endrin Poisoning -- Pakistan . Between July 14, and September 26, 1984, an outbreak of acute convulsions occurred in Talagang, a wheat-growing subdistrict of the Punjab province of Pakistan.

International Notes Acute Convulsions Associated with ...

Animal Toxicology | Request PDF

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Animal Toxicology. Article in ... coenzyme A reductase activity by changing the lipid environment of the enzyme. 32P-labeled cDNA probes were used to study the levels of mRNA coding for 3-hydroxy ...

Animal Toxicology | Request PDF

Toxicity Effects - tools.niehs.nih.gov

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Endrin was tested for mutagenicity in the Salmonella/microsome preincubation assay. Endrin was tested over a wide range of doses (0, 100, 333, 1000, 3333, and 10,000 ug/plate) in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9.

Toxicity Effects - tools.niehs.nih.gov

INTEGRATED RISK INFORMATION SYSTEM - ENDRIN

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including endrin. No statistically significant excesses or deficits in mortality for any specific cancer site were noted. Limited follow-up time (12 years), lack of exposure data, and few deaths give this study low power. II.A.3. Animal Carcinogenicity Data Inadequate. The potential carcinogenic effects of …

INTEGRATED RISK INFORMATION SYSTEM - ENDRIN

Environment Science Ch. 3 (Environmental Toxicology ...

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Environment Science Ch. 3 (Environmental Toxicology) study guide by valerie_hamana includes 63 questions covering vocabulary, terms and more. Quizlet flashcards, activities and games help you improve your grades.

Environment Science Ch. 3 (Environmental Toxicology ...

Toxicology/Carcinogenicity - National Toxicology Program

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NTP performs toxicology/carcinogenicity studies to address the gap in knowledge concerning the toxicity of substances in our environment. These studies are also performed to evaluate dose-response relationships between exposed and unexposed organisms and to determine if a substance elicits toxic effects and/or causes cancer in a biological system.

Toxicology/Carcinogenicity - National Toxicology Program

Endrin: Health Advisory - EPA

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March 31, 1987 ENDRIN Health Advisory Office of Drinking Water U.S. Environmental Protection Agency INTRODUCTION The Health Advisory (HA) Program, sponsored by the Office of Drinking Water (ODW), provides information on the health effects, analytical method- ology and treatment technology that would be useful in dealing with the contamination of drinking water.

Endrin: Health Advisory - EPA
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